Leloir pathway

The Leloir pathway is a metabolic pathway for the catabolism of D-galactose. It is named after Luis Federico Leloir. In the first step α-D-galactose is phosphorylated by a kinase to galactose 1-phosphate. Also part of this pathway is a mutarotase that facilitates the conversion of β-D-galactose to α-D-galactose since the kinase is only active with the α-form of D-galactose. D-galactose-1-phosphate uridylyltransferase is producing D-glucose 1-phosphate; UDP-galactose-4-epimerase is to recycle the UDP-galactose to UDP-glucose for the transferase reaction and phosphoglucomutase converts the D-glucose 1-phosphate to D-glucose 6-phosphate.[2][3]

References

  1. ^ Holden HM, Rayment I, Thoden JB (November 2003). "Structure and function of enzymes of the Leloir pathway for galactose metabolism". J. Biol. Chem. 278 (45): 43885–8. doi:10.1074/jbc.R300025200. PMID 12923184. 
  2. ^ Frey PA (March 1996). "The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose". FASEB J. 10 (4): 461–70. PMID 8647345. http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=8647345. Retrieved 2011-04-01. 
  3. ^ Garrett, Reginald; Grisham, Charles M. (2010), Biochemistry (4 ed.), Cengage Learning, p. 556, ISBN 9780495109358, http://books.google.co.uk/books?id=iGPsen3fSOIC&pg=PA556&ved=0CC0Q6AEwAA#v=onepage&q&f=false